PI(4,5)P2 and L-type Ca(2+) Channels Partner Up to Fine-Tune Ca(2+) Dynamics in ß Cells.

ABSTRACT

The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca(2+) dynamics and insulin secretion in pancreatic ß cells.