PI(4,5)P2 and L-type Ca(2+) Channels Partner Up to Fine-Tune Ca(2+) Dynamics in ß Cells.
Cell Chem Biol
; 23(7): 753-755, 2016 07 21.
Article
em En
| MEDLINE
| ID: mdl-27447044
ABSTRACT
The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca(2+) dynamics and insulin secretion in pancreatic ß cells.
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1
Bases de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
/
Células Secretoras de Insulina
Idioma:
En
Revista:
Cell Chem Biol
Ano de publicação:
2016
Tipo de documento:
Article