Reassuring results on birth outcomes in children fathered by men treated with azathioprine/6-mercaptopurine within 3â
months before conception: a nationwide cohort study.
Gut
; 66(10): 1761-1766, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-27456154
ABSTRACT
OBJECTIVE:
Information on the safety of paternal use of azathioprine (AZA) and 6-mercaptopurine (6-MP) prior to conception is limited. Based on nationwide data from the Danish health registries, we examined the association between paternal use of AZA/6-MP within 3â months before conception and adverse birth outcomes.DESIGN:
This nationwide cohort study is based on data from all singletons born in Denmark from 1 January 1997 through 2013. Children fathered by men who used AZA/6-MP within 3â months before conception constituted the exposed cohort (N=699), and children fathered by men who did not use AZA/6-MP 3â months prior to conception constituted the unexposed cohort (N=1â 012â 624). The outcomes were congenital abnormalities (CAs), preterm birth and small for gestational age (SGA). We adjusted for multiple covariates and performed a restricted analysis of men with IBD.RESULTS:
There were no significantly increased risks of CAs, preterm birth or SGA in exposed versus unexposed cohorts of children. The adjusted ORs were 0.82 (95% CI 0.53 to 1.28) for CAs, 1.17 (95% CI 0.72 to 1.92) for preterm birth and 1.38 (95% CI 0.76 to 2.51) for SGA. Restricting our analysis to fathers with IBD showed similar results with no significantly increased risk of adverse birth outcomes.CONCLUSIONS:
This nationwide study is the largest to date, examining the effect of preconceptual paternal use of AZA/6-MP on birth outcomes in live born singletons. The results of no significantly increased risks of adverse birth outcomes are reassuring and support the continuation of paternal AZA/6-MP treatment during conception.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Anormalidades Congênitas
/
Recém-Nascido Pequeno para a Idade Gestacional
/
Exposição Paterna
/
Nascimento Prematuro
/
Imunossupressores
/
Mercaptopurina
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Gut
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Dinamarca