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Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.
Shi, Xiarong; Sousa, Leiliane P; Mandel-Bausch, Elizabeth M; Tome, Francisco; Reshetnyak, Andrey V; Hadari, Yaron; Schlessinger, Joseph; Lax, Irit.
Afiliação
  • Shi X; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520;
  • Sousa LP; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520;
  • Mandel-Bausch EM; Kolltan Pharmaceuticals Inc., New Haven, CT 06511.
  • Tome F; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520;
  • Reshetnyak AV; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520;
  • Hadari Y; Kolltan Pharmaceuticals Inc., New Haven, CT 06511.
  • Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520; irit.lax@yale.edu joseph.schlessinger@yale.edu.
  • Lax I; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520; irit.lax@yale.edu joseph.schlessinger@yale.edu.
Proc Natl Acad Sci U S A ; 113(33): E4784-93, 2016 08 16.
Article em En | MEDLINE | ID: mdl-27482095
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-kit / Inibidores de Proteínas Quinases / Mutação / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-kit / Inibidores de Proteínas Quinases / Mutação / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article