Identification and comparative oridonin metabolism in different species liver microsomes by using UPLC-Triple-TOF-MS/MS and PCA.

Ma, Yinghua; Xie, Weiwei; Tian, Tingting; Jin, Yiran; Xu, Huijun; Zhang, Kerong; Du, Yingfeng

Ma, Yinghua; Xie, Weiwei; Tian, Tingting; Jin, Yiran; Xu, Huijun; Zhang, Kerong; Du, Yingfeng.

Afiliação

Ma Y; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.
Xie W; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.
Tian T; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.
Jin Y; The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China.
Xu H; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.
Zhang K; Applied Biosystems Trading Co., Ltd., Beijing Branch Office, Beijing 100027, PR China.
Du Y; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China. Electronic address: yingfengdu@hotmail.com.

Anal Biochem ; 511: 61-73, 2016 Oct 15.

Article em En | MEDLINE | ID: mdl-27503750

Assuntos

Diterpenos do Tipo Caurano/farmacocinética; Microssomos Hepáticos/metabolismo; Espectrometria de Massas em Tandem/métodos; Animais; Humanos

Palavras-chave

In vitro; Liver microsomes; Metabolites; Oridonin; UPLC-Triple-TOF-MS/MS

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Diterpenos do Tipo Caurano / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Anal Biochem Ano de publicação: 2016 Tipo de documento: Article

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