Association of rs10811656 on 9P21.3 with the risk of coronary artery disease in a Chinese population.

ABSTRACT

BACKGROUND: Genome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). However, it is not known whether rs10811656 is linked with CAD in a Chinese population. Thus, the purpose of this study was to investigate the potential association between rs10811656 and the risk of CAD in a Chinese population. METHODS: We conducted a hospital-based, case-control study with 251 CAD patients and 304 controls to examine the potential association of rs10811656 with CAD. RESULTS: The frequencies of the TT genotypes in CAD cases were significantly different from those in controls (adjusted OR 1.96, 95 % CI 1.09-3.505, P = 0.024). Compared to controls, rs10811656 was significantly associated with the stable angina pectoris (adjusted OR 1.42, 95 % CI 1.06-1.90, P = 0.017), but not with acute coronary syndrome. There was also a highly significant association of rs10811656 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels (adjusted OR 1.68 and 1.60, 95 % CI 1.14-2.44 and 1.10-2.33, P = 0.009 and 0.02, respectively). CONCLUSION: Our results suggest that the rs10811656 locus might be associated with CAD in a Chinese Han population.