Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs.
Curr HIV/AIDS Rep
; 13(6): 340-348, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27549318
ABSTRACT
Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stressors, predisposing to major adverse clinical outcomes, including hospitalization, institutionalization, disability, and death in the general population of older adults. As the proportion of older adults living with HIV increases in the era of antiretroviral therapy, frailty is increasingly recognized to be of significant clinical and public health relevance to the HIV-infected population. This article reviews current knowledge on the epidemiology and biology of frailty and its potential role as a target for reducing disparities in outcomes in HIV; conceptual frameworks and current approaches to frailty measurement; existing data on frailty interventions; and important areas for future research focus necessary to develop and advance effective strategies to prevent or ameliorate frailty and its marked adverse consequences among people living with HIV.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Infecções por HIV
/
Idoso Fragilizado
Tipo de estudo:
Screening_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
AIDS Rep
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos