Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro.

Chen, D; Lin, X-X; Zhao, Q; Xiao, J; Peng, S-F; Xiao, M-F; Ouyang, D-S; Tan, Z-R; Wang, Y-C; Peng, J-B; Zhang, W; Chen, Y

Chen, D; Lin, X-X; Zhao, Q; Xiao, J; Peng, S-F; Xiao, M-F; Ouyang, D-S; Tan, Z-R; Wang, Y-C; Peng, J-B; Zhang, W; Chen, Y.

Afiliação

Chen D; a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , Hunan , China.
Lin XX; b Institute of Clinical Pharmacology, Central South University , Changsha , Hunan , China.
Zhao Q; a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , Hunan , China.
Xiao J; b Institute of Clinical Pharmacology, Central South University , Changsha , Hunan , China.
Peng SF; a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , Hunan , China.
Xiao MF; b Institute of Clinical Pharmacology, Central South University , Changsha , Hunan , China.
Ouyang DS; c Department of Pharmacy , Xiangya Hospital, Central South University , Changsha , Hunan , China.
Tan ZR; d Department of Hepatology and Infectious Diseases , Xiangya Hospital, Central South University , Changsha , Hunan , China , and.
Wang YC; e Health Management Center, Xiangya Hospital, Central South University , Changsha , Hunan , China.
Peng JB; d Department of Hepatology and Infectious Diseases , Xiangya Hospital, Central South University , Changsha , Hunan , China , and.
Zhang W; e Health Management Center, Xiangya Hospital, Central South University , Changsha , Hunan , China.
Chen Y; a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , Hunan , China.

Xenobiotica ; 47(9): 778-784, 2017 Sep.

Article em En | MEDLINE | ID: mdl-27571049

Assuntos

Ácido Fusídico/metabolismo; Citocromo P-450 CYP1A2/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Interações Medicamentosas; Humanos; Inativação Metabólica/efeitos dos fármacos; Microssomos Hepáticos/metabolismo; Isoformas de Proteínas/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Accumulation; CYP2D6; CYP3A4; drugdrug interaction; fusidic acid

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácido Fusídico Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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