The exposome in practice: Design of the EXPOsOMICS project.
Int J Hyg Environ Health
; 220(2 Pt A): 142-151, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27576363
ABSTRACT
EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Poluição da Água
/
Monitoramento Ambiental
/
Poluição do Ar
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Child
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Int J Hyg Environ Health
Assunto da revista:
SAUDE AMBIENTAL
/
SAUDE PUBLICA
Ano de publicação:
2017
Tipo de documento:
Article