Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily.

Sunden, Fanny; AlSadhan, Ishraq; Lyubimov, Artem Y; Ressl, Susanne; Wiersma-Koch, Helen; Borland, Jamar; Brown, Clayton L; Johnson, Tory A; Singh, Zorawar; Herschlag, Daniel

Sunden, Fanny; AlSadhan, Ishraq; Lyubimov, Artem Y; Ressl, Susanne; Wiersma-Koch, Helen; Borland, Jamar; Brown, Clayton L; Johnson, Tory A; Singh, Zorawar; Herschlag, Daniel.

Afiliação

Sunden F; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
AlSadhan I; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
Lyubimov AY; Departments of Molecular and Cellular Physiology, Neurology and Neurological Science, Structural Biology, and Photon Science, Howard Hughes Medical Institute, Stanford University , Stanford, California 94305, United States.
Ressl S; Molecular and Cellular Biochemistry Department, Indiana University , Bloomington, Indiana 47405, United States.
Wiersma-Koch H; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
Borland J; Department of Biology, Indian River State College , Fort Pierce, Florida 34981, United States.
Brown CL; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
Johnson TA; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
Singh Z; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.
Herschlag D; Department of Biochemistry, Beckman Center, Stanford University , Stanford, California 94305, United States.

J Am Chem Soc ; 138(43): 14273-14287, 2016 11 02.

Article em En | MEDLINE | ID: mdl-27670607

Assuntos

Evolução Molecular; Diester Fosfórico Hidrolases/química; Diester Fosfórico Hidrolases/metabolismo; Monoéster Fosfórico Hidrolases/química; Monoéster Fosfórico Hidrolases/metabolismo; Biocatálise; Domínio Catalítico; Chryseobacterium/enzimologia; Hidrólise; Modelos Moleculares; Mutação; Diester Fosfórico Hidrolases/genética; Monoéster Fosfórico Hidrolases/genética; Especificidade por Substrato; Xanthomonas/enzimologia

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Monoéster Fosfórico Hidrolases / Diester Fosfórico Hidrolases / Evolução Molecular Idioma: En Revista: J Am Chem Soc Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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