A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.

Surmiak, Ewa; Twarda-Clapa, Aleksandra; Zak, Krzysztof M; Musielak, Bogdan; Tomala, Marcin D; Kubica, Katarzyna; Grudnik, Przemyslaw; Madej, Mariusz; Jablonski, Mateusz; Potempa, Jan; Kalinowska-Tluscik, Justyna; Dömling, Alexander; Dubin, Grzegorz; Holak, Tad A

Surmiak, Ewa; Twarda-Clapa, Aleksandra; Zak, Krzysztof M; Musielak, Bogdan; Tomala, Marcin D; Kubica, Katarzyna; Grudnik, Przemyslaw; Madej, Mariusz; Jablonski, Mateusz; Potempa, Jan; Kalinowska-Tluscik, Justyna; Dömling, Alexander; Dubin, Grzegorz; Holak, Tad A.

Afiliação

Surmiak E; Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
Twarda-Clapa A; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Gronostajowa 7, 30-387 Krakow, Poland.
Zak KM; Malopolska Centre of Biotechnology, Jagiellonian University , Gronostajowa 7a, 30-387 Krakow, Poland.
Musielak B; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Gronostajowa 7, 30-387 Krakow, Poland.
Tomala MD; Malopolska Centre of Biotechnology, Jagiellonian University , Gronostajowa 7a, 30-387 Krakow, Poland.
Kubica K; Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
Grudnik P; Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
Madej M; Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
Jablonski M; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Gronostajowa 7, 30-387 Krakow, Poland.
Potempa J; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Gronostajowa 7, 30-387 Krakow, Poland.
Kalinowska-Tluscik J; Malopolska Centre of Biotechnology, Jagiellonian University , Gronostajowa 7a, 30-387 Krakow, Poland.
Dömling A; Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
Dubin G; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , Gronostajowa 7, 30-387 Krakow, Poland.
Holak TA; Malopolska Centre of Biotechnology, Jagiellonian University , Gronostajowa 7a, 30-387 Krakow, Poland.

ACS Chem Biol ; 11(12): 3310-3318, 2016 12 16.

Article em En | MEDLINE | ID: mdl-27709883

Assuntos

4-Butirolactona/análogos & derivados; Mapas de Interação de Proteínas/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-mdm2/antagonistas & inibidores; Pirróis/química; Pirróis/farmacologia; Proteína Supressora de Tumor p53/antagonistas & inibidores; 4-Butirolactona/química; 4-Butirolactona/farmacologia; Cristalografia por Raios X; Desenho de Fármacos; Humanos; Modelos Moleculares; Conformação Proteica; Multimerização Proteica/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-mdm2/química; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; Relação Estrutura-Atividade; Proteína Supressora de Tumor p53/química; Proteína Supressora de Tumor p53/metabolismo

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Bases de dados: MEDLINE Assunto principal: Pirróis / 4-Butirolactona / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Mapas de Interação de Proteínas Limite: Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Polônia

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