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Chondrocyte FGFR3 Regulates Bone Mass by Inhibiting Osteogenesis.
Wen, Xuan; Li, Xiaogang; Tang, Yubin; Tang, Junzhou; Zhou, Siru; Xie, Yangli; Guo, Jingyuan; Yang, Jing; Du, Xiaolan; Su, Nan; Chen, Lin.
Afiliação
  • Wen X; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Li X; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Tang Y; the 305 Hospital of Chinese People's Liberation Army, Beijing 100017, and.
  • Tang J; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Zhou S; the Department of Emergency Treatment, Lanzhou General Hospital, Lanzhou Command, Chinese People's Liberation Army, Lanzhou 730050, China.
  • Xie Y; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Guo J; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Yang J; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Du X; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Su N; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
  • Chen L; From the Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
J Biol Chem ; 291(48): 24912-24921, 2016 Nov 25.
Article em En | MEDLINE | ID: mdl-27729453
ABSTRACT
Chondrogenesis can regulate bone formation. Fibroblast growth factor receptor 3, highly expressed in chondrocytes, is a negative regulator of bone growth. To investigate whether chondrocyte FGFR3 regulates osteogenesis, thereby contributing to postnatal bone formation and bone remodeling, mice with conditional knock-out of Fgfr3 in chondrocytes (mutant (MUT)) were generated. MUT mice displayed overgrowth of bone with lengthened growth plates. Bone mass of MUT mice was significantly increased at both 1 month and 4 months of age. Histological analysis showed that osteoblast number and bone formation were remarkably enhanced after deletion of Fgfr3 in chondrocytes. Chondrocyte-osteoblast co-culture assay further revealed that Fgfr3 deficiency in chondrocytes promoted differentiation and mineralization of osteoblasts by up-regulating the expressions of Ihh, Bmp2, Bmp4, Bmp7, Wnt4, and Tgf-ß1, as well as down-regulating Nog expression. In addition, osteoclastogenesis was also impaired in MUT mice with decreased number of osteoclasts lining trabecular bone, which may be related to the reduced ratio of Rankl to Opg in Fgfr3-deficient chondrocytes. This study reveals that chondrocyte FGFR3 is involved in the regulation of bone formation and bone remodeling by a paracrine mechanism.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Osteogênese / Condrócitos / Comunicação Parácrina / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Osteoprotegerina / Lâmina de Crescimento Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Osteogênese / Condrócitos / Comunicação Parácrina / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Osteoprotegerina / Lâmina de Crescimento Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article