Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway.
J Dermatol Sci
; 85(1): 20-26, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27743912
ABSTRACT
BACKGROUND:
Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied.OBJECTIVE:
Study the expression of cytokines and chemokines involved in the IL-17/IL-23 axis in palmoplantar pustular psoriasis and other difficult to treat psoriasis areas (palms, scalp, elbows and lower legs).METHODS:
Skin biopsies were performed on a total of 80 patients with PPPP, non-pustular palmoplantar psoriasis (NPPPP), or psoriasis located on elbows, knees and scalp as well as 10 healthy subjects. RT-PCR, immunohistochemistry and flow cytometry on cells extracted from skin biopsies were used to compare PPPP to other forms of psoriasis.RESULTS:
There was a significant (p<0.05) increase in the expression of IL-1ß, IL-6, LL-37, IL-19, IL-17A, CXCL1 and CXCL2 in PPPP as compared to NPPPP. However, there was no significant difference in expression of IL-23 in PPPP as compared to NPPPP and other forms of psoriasis. The proportion of IL-22+ but not IL-17A+ mast cells was higher in PPPP as compared to NPPPP (p<0.05).CONCLUSION:
These results suggest that the IL-17A pathway may play a more important role in PPPP than in NPPPP.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Psoríase
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Citocinas
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Interleucina-17
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Subunidade p19 da Interleucina-23
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Dermatol Sci
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article