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An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
Villa, Genaro R; Hulce, Jonathan J; Zanca, Ciro; Bi, Junfeng; Ikegami, Shiro; Cahill, Gabrielle L; Gu, Yuchao; Lum, Kenneth M; Masui, Kenta; Yang, Huijun; Rong, Xin; Hong, Cynthia; Turner, Kristen M; Liu, Feng; Hon, Gary C; Jenkins, David; Martini, Michael; Armando, Aaron M; Quehenberger, Oswald; Cloughesy, Timothy F; Furnari, Frank B; Cavenee, Webster K; Tontonoz, Peter; Gahman, Timothy C; Shiau, Andrew K; Cravatt, Benjamin F; Mischel, Paul S.
Afiliação
  • Villa GR; Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA; Medical Scientist Training Program, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla
  • Hulce JJ; Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Zanca C; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Bi J; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Ikegami S; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Cahill GL; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Gu Y; Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Lum KM; Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Masui K; Department of Pathology, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
  • Yang H; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Rong X; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Hong C; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Turner KM; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Liu F; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Hon GC; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Jenkins D; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Martini M; Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Armando AM; Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093, USA.
  • Quehenberger O; Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093, USA; Department of Medicine, UCSD School of Medicine, La Jolla, CA 92093, USA.
  • Cloughesy TF; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Furnari FB; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA.
  • Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA.
  • Tontonoz P; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Gahman TC; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Shiau AK; Small Molecule Discovery Program, Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.
  • Cravatt BF; Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.
  • Mischel PS; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address: pmischel@ucsd.edu.
Cancer Cell ; 30(5): 683-693, 2016 Nov 14.
Article em En | MEDLINE | ID: mdl-27746144
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Colesterol / Glioblastoma / Receptores X do Fígado / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Colesterol / Glioblastoma / Receptores X do Fígado / Indazóis Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article