MRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis.
Clin Exp Rheumatol
; 34(6): 991-998, 2016.
Article
em En
| MEDLINE
| ID: mdl-27749237
ABSTRACT
OBJECTIVES:
To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA.METHODS:
The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used clinical assessment (pain, swelling, stiffness and function Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1ß and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand. Associations between clinical, biomarker and imaging findings were assessed using the Spearman correlation coefficient and test.RESULTS:
18 patients were recruited, and 144 joints studied. A correlation was found between clinical features (pain, FIHOA, CHFS) and the Verbruggen score (respectively p=0.05, r=0.47; p=0.05, r=0.48; p=0.05, r=0.48). Serum IL-1 level was strongly associated with loss of function (FIHOA p=0.02, r=-0.73; CHFS p=0.01, r=-0.76) and radiological erosions (p=0.03, r=0.7) as with urinary CTX2. A significant association was found between MRI osteophytes and usCRP (p=0.0026). MRI and radiological features were significantly correlated except for synovitis and bone marrow lesions.CONCLUSIONS:
MRI synovitis was not correlated with radiological scores, clinical or biologic markers of inflammation. There was a strong correlation between other MRI features and radiological scores. Serum IL-1 level was associated with structural damage and function.
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Bases de dados:
MEDLINE
Assunto principal:
Osteoartrite
/
Articulação da Mão
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França