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Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.
Wurz, Ryan P; Sastri, Christine; D'Amico, Derin C; Herberich, Brad; Jackson, Claire L M; Pettus, Liping H; Tasker, Andrew S; Wu, Bin; Guerrero, Nadia; Lipford, J Russell; Winston, Jeffrey T; Yang, Yajing; Wang, Paul; Nguyen, Yen; Andrews, Kristin L; Huang, Xin; Lee, Matthew R; Mohr, Christopher; Zhang, J D; Reid, Darren L; Xu, Yang; Zhou, Yihong; Wang, Hui-Ling.
Afiliação
  • Wurz RP; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. Electronic address: rwurz@amgen.com.
  • Sastri C; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. Electronic address: csastri@amgen.com.
  • D'Amico DC; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Herberich B; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Jackson CLM; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Pettus LH; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Tasker AS; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wu B; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Guerrero N; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Lipford JR; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Winston JT; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Yang Y; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wang P; Department of Discovery Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Nguyen Y; Department of Discovery Attribute Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Andrews KL; Department of Molecular Engineering, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Huang X; Department of Molecular Engineering, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Lee MR; Department of Molecular Engineering, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Mohr C; Department of Molecular Engineering, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Zhang JD; Department of Molecular Engineering, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Reid DL; Department of Pre-pivotal Drug Product, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Xu Y; Department of Clinical Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Zhou Y; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wang HL; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
Bioorg Med Chem Lett ; 26(22): 5580-5590, 2016 11 15.
Article em En | MEDLINE | ID: mdl-27769621
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piridazinas / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piridazinas / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article