The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted.
Atherosclerosis
; 255: 11-16, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27794213
ABSTRACT
BACKGROUND AND AIMS:
We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness.METHODS:
We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium.RESULTS:
Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50-90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7-8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher.CONCLUSIONS:
The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better - i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doenças das Artérias Carótidas
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Artéria Carótida Primitiva
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Síndrome Metabólica
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Espessura Intima-Media Carotídea
/
Remodelação Vascular
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America do norte
/
Asia
/
Europa
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
2016
Tipo de documento:
Article