Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression.
Physiol Behav
; 45(5): 1067-8, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2780868
ABSTRACT
In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84 +/- 6.54 sec in sham-ovariectomized mice and 113.11 +/- 7.86 sec 30-32 days after ovariectomy. Estradiol (10, 100 or 1,000 micrograms/kg) and progesterone (50, 1,000 or 10,000 micrograms/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On the other hand, desipramine (20 mg/kg IP 1 hr before testing) significantly reduced the duration of immobility both in ovariectomized and in sham-operated mice. These data indicate that ovarian sex hormones, while having no "antidepressant," desipramine-like, effect on the behavior of intact adult female mice, have such an effect in ovariectomized mice, and enable the animal to cope in a "normal" way with adverse environmental situations.
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Bases de dados:
MEDLINE
Assunto principal:
Progesterona
/
Comportamento Animal
/
Ovariectomia
/
Depressão
/
Estradiol
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Itália