Co-Translational Folding: A Novel Modulator of Local Protein Expression in Mammalian Neurons?
Trends Genet
; 32(12): 788-800, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27817871
ABSTRACT
Local protein expression at synapses is a prerequisite for learning in mammalian neurons. It has been shown that a subset of RNAs is localized in dendrites. These transcripts are first assembled into ribonucleoprotein particles in the cell body and are then transported along the cytoskeleton to or near synapses in a translationally repressed state. However, we know very little about the underlying mechanisms of local translation as well as potential protein degradation. Research in the last years showed many features of general translation. One very interesting aspect with raising attention is co-translational folding, a process that guides protein folding during ribosome elongation. In this review, we propose that translation speed is influenced by the codon usage of localized transcripts, which in turn affects protein folding and ultimately degradation efficiency. Together, these processes significantly contribute to synaptic proteome changes and synaptic plasticity. Furthermore, we envision that co-translational misfolding could contribute to neurodegenerative diseases.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
RNA
/
Processamento de Proteína Pós-Traducional
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Trends Genet
Assunto da revista:
GENETICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha