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FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.
Ihara, K; Fukano, C; Ayabe, T; Fukami, M; Ogata, T; Kawamura, T; Urakami, T; Kikuchi, N; Yokota, I; Takemoto, K; Mukai, T; Nishii, A; Kikuchi, T; Mori, T; Shimura, N; Sasaki, G; Kizu, R; Takubo, N; Soneda, S; Fujisawa, T; Takaya, R; Kizaki, Z; Kanzaki, S; Hanaki, K; Matsuura, N; Kasahara, Y; Kosaka, K; Takahashi, T; Minamitani, K; Matsuo, S; Mochizuki, H; Kobayashi, K; Koike, A; Horikawa, R; Teno, S; Tsubouchi, K; Mochizuki, T; Igarashi, Y; Amemiya, S; Sugihara, S.
Afiliação
  • Ihara K; Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Fukano C; Department of Paediatrics, Oita University School of Medicine, Yufu, Japan.
  • Ayabe T; Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Fukami M; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Ogata T; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Kawamura T; Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Urakami T; Department of Paediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Kikuchi N; Department of Paediatrics, Osaka City University Hospital, Osaka, Japan.
  • Yokota I; Department of Paediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Takemoto K; Department of Paediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
  • Mukai T; Department of Clinical Laboratory, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.
  • Nishii A; Department of Paediatrics, Graduate School of Medical Sciences Tokushima University, Tokushima, Japan.
  • Kikuchi T; Department of Paediatrics, Ehime University Hospital, Toon, Japan.
  • Mori T; Department of Paediatrics, Sumitomo Besshi Hospital, Niihama, Japan.
  • Shimura N; Department of Paediatrics, Asahikawa Medical University Hospital, Asahikawa, Japan.
  • Sasaki G; Department of Paediatrics, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
  • Kizu R; Department of Paediatrics, JR Sendai Hospital, Sendai, Japan.
  • Takubo N; Department of Paediatrics, Saitama Medical University Hospital, Saitama, Japan.
  • Soneda S; Department of Paediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan.
  • Fujisawa T; Department of Paediatrics, Nagano Red Cross Hospital, Nagano, Japan.
  • Takaya R; Department of Paediatrics, Shinshu Ueda Medical Centre, Ueda, Japan.
  • Kizaki Z; Department of Paediatrics, Dokkyo Medical University Hospital, Shimotsuga, Japan.
  • Kanzaki S; Department of Paediatrics, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
  • Hanaki K; Department of Paediatrics, Yokosuka Kyosai Hospital, Yokosuka, Japan.
  • Matsuura N; Department of Pediatrics, Kitasato University Hospital, Sagamihara, Japan.
  • Kasahara Y; Department of Paediatrics and Adolescent Medicine, Juntendo University School of Medicine, Tokyo, Japan.
  • Kosaka K; Department of Paediatrics, St Marianna University School of Medicine, Kawasaki, Japan.
  • Takahashi T; Department of Paediatrics, National Mie Hospital, Tsu, Japan.
  • Minamitani K; Department of Paediatrics, Osaka Medical College, Takatsuki, Japan.
  • Matsuo S; Department of Paediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
  • Mochizuki H; Department of Paediatrics, Tottori University Faculty of Medicine, Yonago, Japan.
  • Kobayashi K; Department of Paediatrics, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan.
  • Koike A; Department of Paediatrics, Teine Keijinkai Hospital, Sapporo, Japan.
  • Horikawa R; Department of Early Childhood Care and Education, Seitoku University Junior College, Matsudo, Japan.
  • Teno S; Department of Paediatrics, Kanazawa University, Kanazawa, Japan.
  • Tsubouchi K; Department of Paediatrics, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Mochizuki T; Takahashi Clinic, Kobe, Japan.
  • Igarashi Y; Department of Paediatrics, Teikyo University Chiba Medical Center, Ichihara, Japan.
  • Amemiya S; Matsuo Kodomo Clinic, Kyoto, Japan.
  • Sugihara S; Department of Metabolism and Endocrinology, Saitama Children's Medical Centre, Saitama, Japan.
Diabet Med ; 34(4): 586-589, 2017 04.
Article em En | MEDLINE | ID: mdl-27859559
ABSTRACT

AIM:

To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children.

METHODS:

We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined.

RESULTS:

The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20-2.35); corrected P value = 0.0075].

CONCLUSIONS:

The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Fucosiltransferases Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Diabet Med Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Fucosiltransferases Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Diabet Med Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão