JET2 Viewer: a database of predicted multiple, possibly overlapping, protein-protein interaction sites for PDB structures.
Nucleic Acids Res
; 45(D1): D236-D242, 2017 01 04.
Article
em En
| MEDLINE
| ID: mdl-27899675
ABSTRACT
The database JET2 Viewer, openly accessible at http//www.jet2viewer.upmc.fr/, reports putative protein binding sites for all three-dimensional (3D) structures available in the Protein Data Bank (PDB). This knowledge base was generated by applying the computational method JET2 at large-scale on more than 20 000 chains. JET2 strategy yields very precise predictions of interacting surfaces and unravels their evolutionary process and complexity. JET2 Viewer provides an online intelligent display, including interactive 3D visualization of the binding sites mapped onto PDB structures and suitable files recording JET2 analyses. Predictions were evaluated on more than 15 000 experimentally characterized protein interfaces. This is, to our knowledge, the largest evaluation of a protein binding site prediction method. The overall performance of JET2 on all interfaces are Sen = 52.52, PPV = 51.24, Spe = 80.05, Acc = 75.89. The data can be used to foster new strategies for protein-protein interactions modulation and interaction surface redesign.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Mapeamento de Interação de Proteínas
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Bases de Dados de Proteínas
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França