Association of polymorphisms in the telomere-related gene ACYP2 with lung cancer risk in the Chinese Han population.
Oncotarget
; 7(52): 87473-87478, 2016 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-27974682
ABSTRACT
Single nucleotide polymorphisms (SNPs) in the telomere-associated gene ACYP2 are associated with increased lung cancer risk. We explored the correlation between ACYP2 SNPs and lung cancer susceptibility in the Chinese Han population. A total of 554 lung cancer patients and 603 healthy controls were included in this study. Thirteen SNPs in ACYP2 were selected. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used assess the correlation between SNPs and lung cancer. We found that rs1682111 was associated with increased lung cancer risk in the recessive model (crude, OR=1.50, 95%CI 1.04-2.16, p=0.029; adjusted for age, OR=1.55, 95%CI 1.04-2.30, p=0.029), as was rs11896604 in the codominant model (crude, OR=0.65, 95%CI 0.33-1.28, p=0.045; adjusted for age, OR=0.74, 95%CI 0.36-1.53, p=0.049) and over-dominant model (crude, OR=1.30, 95%CI 1.02-1.66, p=0.032; adjusted for age, OR=1.37, 95%CI 1.05-1.78, p=0.020). Finally, rs843720 was associated with increased lung cancer risk in the recessive model (crude, OR=1.43, 95%CI 1.02-2.02, p=0.040; adjusted for age, OR=1.48, 95%CI 1.02-2.15, p=0.040). Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
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Bases de dados:
MEDLINE
Assunto principal:
Hidrolases Anidrido Ácido
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oncotarget
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China