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The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine.
Broekman, M M T J; Wong, D R; Wanten, G J A; Roelofs, H M; van Marrewijk, C J; Klungel, O H; Verbeek, A L M; Hooymans, P M; Guchelaar, H-J; Scheffer, H; Derijks, L J J; Coenen, M J H; de Jong, D J.
Afiliação
  • Broekman MMTJ; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands.
  • Wong DR; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.
  • Wanten GJA; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands.
  • Roelofs HM; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands.
  • van Marrewijk CJ; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
  • Klungel OH; Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands.
  • Verbeek ALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
  • Hooymans PM; Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.
  • Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
  • Scheffer H; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
  • Derijks LJJ; Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, The Netherlands.
  • Coenen MJH; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Human Genetics, Nijmegen, The Netherlands.
  • de Jong DJ; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gastroenterology, Nijmegen, The Netherlands.
Pharmacogenomics J ; 18(1): 160-166, 2018 01.
Article em En | MEDLINE | ID: mdl-28045129
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Azatioprina / Tioinosina / Tionucleotídeos / Anti-Inflamatórios não Esteroides / Glutationa Transferase / Imunossupressores Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacogenomics J Assunto da revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Azatioprina / Tioinosina / Tionucleotídeos / Anti-Inflamatórios não Esteroides / Glutationa Transferase / Imunossupressores Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pharmacogenomics J Assunto da revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda