Pattern- and motion-related visual evoked potentials in HIV-infected adults.
Doc Ophthalmol
; 134(1): 45-55, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-28074347
ABSTRACT
PURPOSE:
The goal of the current study was to explore visual function in virally suppressed HIV patients undergoing combined antiretroviral therapy (cART) by using pattern-reversal and motion-onset visual evoked potentials (VEPs).METHODS:
The pattern-reversal and motion-onset VEPs were recorded in 20 adult HIV+ patients with a mean age of 38 years and CD4 cell counts ≥230 × 106 cells/L of blood.RESULTS:
Nine out of 20 patients displayed VEP abnormalities. Pattern-reversal VEPs pathology was observed in 20% of subjects, and 45% HIV patients had impaired motion-onset VEPs. Five out of 16 neurologically asymptomatic HIV patients had prolonged motion-onset VEP latencies in both eyes. Four neurologically symptomatic patients displayed simultaneously abnormal motion-onset and pattern-reversal VEP latencies monocular involvement was observed in two patients with Lyme and cytomegalovirus unilateral optic neuritis. Binocular involvement was noted in two patients with cognitive deficits. Correlation analysis between disease duration, CD4 cell count, HIV copies in plasma, MoCA and electrophysiological parameters did not show any significant relationships.CONCLUSIONS:
The functional changes of the visual system in neurologically asymptomatic virally suppressed HIV patients displayed higher motion-onset VEP sensitivity than in standard pattern-reversal VEP examinations. This promising marker, however, has no significant association with clinical conditions. Further exploration is warranted.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Reconhecimento Visual de Modelos
/
Infecções por HIV
/
Potenciais Evocados Visuais
/
Percepção de Movimento
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Doc Ophthalmol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
República Tcheca