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Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults.
Kaur, Sonya; Birdsill, Alex C; Steward, Kayla; Pasha, Evan; Kruzliak, Peter; Tanaka, Hirofumi; Haley, Andreana P.
Afiliação
  • Kaur S; Department of Psychology, The University of Texas at Austin, 108 East Dean Keeton, Stop A8000, Austin, TX, 78712, USA.
  • Birdsill AC; Department of Psychology, The University of Texas at Austin, 108 East Dean Keeton, Stop A8000, Austin, TX, 78712, USA.
  • Steward K; Department of Psychology, The University of Texas at Austin, 108 East Dean Keeton, Stop A8000, Austin, TX, 78712, USA.
  • Pasha E; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
  • Kruzliak P; International Clinical Research Center, St Anne's University Hospital, Brno, Czech Republic.
  • Tanaka H; Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
  • Haley AP; Department of Psychology, The University of Texas at Austin, 108 East Dean Keeton, Stop A8000, Austin, TX, 78712, USA. haley@austin.utexas.edu.
Metab Brain Dis ; 32(3): 727-733, 2017 06.
Article em En | MEDLINE | ID: mdl-28144886
ABSTRACT
Excessive adipose tissue, particularly with a central distribution, consists of visceral fat, which is metabolically active and could impinge upon central nervous system functioning. The aim of the current study was to examine levels of visceral adiposity in relation to key cerebral metabolite ratios localized in the occipitoparietal grey matter. Seventy-three adults, aged between 40 and 60 years, underwent structural magnetic resonance imaging and single voxel 1H Magnetic Resonance Spectroscopy (1H MRS). Visceral fat was assessed using Dual Energy X Ray Absorptiometry (DXA). Individuals with higher visceral fat mass and volume had significantly lower ratios of N-acetyl-aspartate to total creatine (phosphocreatine + creatine, PCr + Cr) (NAA/PCr + Cr) (ß = -0.29, p = 0.03, ß = -0.28, p = 0.04). They also had significantly higher ratios of myo-inositol to total creatine (mI/PCr + Cr ) (ß = 0.36, p = 0.01, ß = 0.36, p = 0.01). Visceral fat mass and volume were not significantly related to ratios of glutamate to total creatine (Glu/PCr + Cr). While future studies are necessary, these results indicate central adiposity is associated with metabolic changes that could impinge upon the central nervous system in middle age.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Lobo Parietal / Ácido Aspártico / Gordura Intra-Abdominal / Lobo Occipital Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Lobo Parietal / Ácido Aspártico / Gordura Intra-Abdominal / Lobo Occipital Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Metab Brain Dis Assunto da revista: CEREBRO / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos