Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans.
Br J Cancer
; 116(5): 688-696, 2017 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-28152549
ABSTRACT
BACKGROUND:
Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS:
A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (11). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS:
For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS:
Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Zinco
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Neoplasias do Sistema Biliar
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Carcinoma Hepatocelular
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Cobre
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Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França