Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis.
Thorax
; 72(10): 946-949, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28159773
ABSTRACT
The impact of immunosuppression on interferon-γ release assays and novel cytokine biomarkers of TB infection, mycobacteria-specific IL-2, IP-10 and TNF-α responses was investigated in an ex vivo model. Cytokine responses in standard QuantiFERON-TB Gold in-Tube (QFT-GIT) assays were compared with duplicate assays containing dexamethasone or infliximab. Dexamethasone converted QFT-GIT results from positive to negative in 30% of participants. Antigen-stimulated interferon-γ, IL-2 and TNF-α responses were markedly reduced, but IP-10 responses were preserved. Infliximab caused QFT-GIT result conversion in up to 30% of participants and substantial reductions in all cytokine responses. Therefore, corticosteroids and anti-TNF-α agents significantly impair interferon-γ release assay performance. IP-10 may be a more robust TB biomarker than interferon-γ in patients receiving corticosteroids.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Corticosteroides
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Antirreumáticos
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Tuberculose Latente
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Testes de Liberação de Interferon-gama
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Infliximab
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Thorax
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido