Corpus callosum volumes in bipolar disorders and suicidal vulnerability.
Psychiatry Res Neuroimaging
; 262: 47-54, 2017 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-28232274
ABSTRACT
Reduced size of the corpus callosum (CC) has been associated with bipolar disorders and suicidality. Here, we aimed at investigating the relative independence of these associations in a large sample of patients. Two samples of males and females totaling 209 euthymic participants were recruited, including 72 patients with a major depressive disorder, 64 with bipolar disorders and 73 healthy controls. Among patients, 61 had a lifetime history of suicide attempt and 75 had none. Structural scans were acquired with 1.5T magnetic resonance imaging. Surface-based morphometry (Freesurfer) analysis was used to compute the volumes of the CC. In the whole sample, there was a significant reduction in the volume of mid-anterior, central, and mid-posterior (all p<0.008) CC in bipolar patients independently from suicidality, with medium effect sizes between unipolar and bipolar patients (Cohen's d between 0.46 and 0.62). In contrast, suicide attempters did not differ from non-attempters. This significant association between CC volumes and bipolar disorders was mainly found in the male sample, while a trend was found in the female sample. Within each patient group, medication had no major effect. Our study adds to the growing body of evidence linking corpus callosum alterations and bipolar disorders.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Tentativa de Suicídio
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Transtorno Bipolar
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Corpo Caloso
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Transtorno Depressivo Maior
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Ideação Suicida
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Psychiatry Res Neuroimaging
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá