Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation.
Trends Biochem Sci
; 42(5): 369-382, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28268044
ABSTRACT
Eukaryotic cells determine the final protein output of their genetic program not only by controlling transcription but also by regulating the localization, translation and turnover rates of their mRNAs. Ultimately, the fate of any given mRNA is determined by the ensemble of all associated RNA-binding proteins (RBPs), non-coding RNAs and metabolites collectively known as the messenger ribonucleoprotein particle (mRNP). Although many mRNA-associated factors have been identified over the past years, little is known about the composition of individual mRNPs and the cooperation of their constituents. In this review we discuss recent progress that has been made on how this 'mRNP code' is established on individual transcripts and how it is interpreted during gene expression in eukaryotic cells.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
RNA
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Processamento de Proteína Pós-Traducional
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2017
Tipo de documento:
Article