Chronic schistosomiasis during pregnancy epigenetically reprograms T-cell differentiation in offspring of infected mothers.
Eur J Immunol
; 47(5): 841-847, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28271497
ABSTRACT
Schistosomiasis is a nontransplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether in utero exposure to chronic schistosome infection (Reg phase) in mice affects B-cell and T-cell development. Therefore, we focused our analyses on T-cell differentiation capacity induced by epigenetic changes in promoter regions of signature cytokines in offspring. Here, we show that naïve T cells from offspring of schistosome infected female mice had a strong capacity to differentiate into TH 1 cells, whereas TH 2 differentiation was impaired. In accordance, reduced levels of histone acetylation of the IL-4 promoter regions were observed in naïve T cells. To conclude, our mouse model revealed distinct epigenetic changes within the naïve T-cell compartment affecting TH 2 and TH 1 cell differentiation in offspring of mothers with chronic helminth infection. These findings could eventually help understand how helminths alter T-cell driven immune responses induced by allergens, bacterial or viral infections, as well as vaccines.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Esquistossomose
/
Ativação Linfocitária
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Linfócitos T
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Diferenciação Celular
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Complicações Parasitárias na Gravidez
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Epigênese Genética
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha