Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort.
Clin Chem
; 63(5): 980-989, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28280052
ABSTRACT
BACKGROUND:
Advanced glycation end products (AGEs) and their receptors are regarded as central to the development of diabetic complications, but associations with diabetes and cardiometabolic outcomes in previous studies are mixed.METHODS:
Using ELISA assays, we measured N(6)-carboxymethyllysine (AGE-CML), soluble receptor for AGEs (sRAGE), and endogenous secreted receptor for AGEs (esRAGE) in 1874 participants from the Atherosclerosis Risk in Communities study. We conducted a cross-sectional analysis to evaluate associations of these biomarkers with demographics, diabetes, hyperglycemia, cardiometabolic measures, and genetic variants in the gene encoding RAGE, AGER (advanced glycosylation end-product specific receptor).RESULTS:
After adjustment for demographics and body mass index (BMI), there were no significant differences in AGE-CML, sRAGE, or esRAGE by diabetes or hemoglobin A1c. Black race and AGER genetic variants were strongly associated with lower sRAGE and esRAGE even after adjustment [percent difference (95% CI) in black vs whites in sRAGE -29.17 (-34.86 to -23.48), esRAGE -26.97 (-33.11 to -20.84); with rs2070600 in sRAGE -30.13 (-40.98 to -19.29), and esRAGE -30.32 (-42.42 to -18.21); with rs2071288 in sRAGE -20.03 (-34.87 to -5.18), and esRAGE -37.70 (-55.75 to -19.65)]. Estimated glomerular filtration rate and albuminuria significantly correlated with sRAGE and esRAGE. BMI and C-reactive protein significantly negatively correlated with AGE-CML, sRAGE, and esRAGE. AGE-CML was modestly correlated with fructosamine and glycated albumin.CONCLUSIONS:
AGE-CML, sRAGE, and esRAGE were more related to genetic, kidney, and inflammatory measures than to diabetes in this community-based population. Our results suggest that, when measured by ELISA, these biomarkers lack specificity and are of limited value in evaluating the role of these compounds in diabetes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Doenças das Artérias Carótidas
/
Diabetes Mellitus
/
Receptor para Produtos Finais de Glicação Avançada
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Chem
Assunto da revista:
QUIMICA CLINICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Moldávia