Beyond white light: optical enhancement in conjunction with magnification colonoscopy for the assessment of mucosal healing in ulcerative colitis.
Endoscopy
; 49(6): 553-559, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28315280
ABSTRACT
Background and study aim The I-SCAN optical enhancement (OE) system with magnification is a recently introduced combination of optical and digital electronic virtual chromoendoscopy, which enhances mucosal and vascular details. The aim of this pilot study was to investigate the use of I-SCAN OE in the assessment of inflammatory changes in ulcerative colitis (UC). Patients and methods A total of 41 consecutive patients with UC and 9 control patients were examined by I-SCAN OE (Pentax Medical, Tokyo, Japan). Targeted biopsies of the imaged areas were obtained. A new optical enhancement score focusing on mucosal and vascular changes was developed. The diagnostic accuracy of I-SCAN OE was calculated against histology using two UC histological scoresâ-âRobarts Histopathology Index (RHI) and ECAP (Extent, Chronicity, Activity, Plus additional findings). Results The overall I-SCAN OE score correlated with ECAP (râ=â0.70; Pâ<â0.001). The accuracy of the overall I-SCAN OE score to detect abnormalities by ECAP was 80â% (sensitivity 78â%, specificity 100â%). I-SCAN OE vascular and mucosal scores correlated with ECAP (râ=â0.65 and 0.71, respectively; Pâ<â0.001). The correlation between overall I-SCAN OE score and RHI was râ=â0.61 (Pâ<â0.01), and the accuracy to detect abnormalities by RHI was 68â% (sensitivity 78â%, specificity 50â%). The majority of patients with Mayo 0 had abnormalities on I-SCAN OE. Conclusion In UC, the new I-SCAN OE technology accurately identified mucosal inflammation, and correlated well with histological scores of chronic and acute changes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
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Colonoscopia
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Imagem Óptica
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Mucosa Intestinal
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Endoscopy
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá