Moderate selenium dosing inhibited chromium (VI) toxicity in chicken liver.
J Biochem Mol Toxicol
; 31(8)2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28321998
ABSTRACT
This study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]-induced damage in chicken liver. A total of 105 chickens were randomly divided into seven groups of 15. Group I received deionized water; group II received Cr(VI) (7.83 mg/kg/d) alone; and other groups orally received both Cr(VI) (7.83 mg/kg/d) and Se of different doses (0.14, 0.29, 0.57, 1.14, and 2.28 mg/kg/d). The levels of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca2+ -ATPase, and mitochondrial membrane potential (MMP) were measured. Results showed that Cr(VI) increased MDA content and decreased GSH content, T-SOD activity, Ca2+ -ATPase activity, and MMP level. Meanwhile, Se co-treatment (0.14, 0.29, and 0.57 mg/kg/d) increased the viability of the above indicators compared with Cr(VI)-treatment alone. In addition, histopathologic examination revealed that Cr(VI) can cause liver damage, whereas Se supplementation of moderate dose inhibited this damage. This study confirmed that Se exerted protective effect against Cr(VI)-induced liver damage.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Selênio
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Cromo
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Doença Hepática Induzida por Substâncias e Drogas
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Fígado
Limite:
Animals
Idioma:
En
Revista:
J Biochem Mol Toxicol
Assunto da revista:
BIOLOGIA MOLECULAR
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BIOQUIMICA
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TOXICOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article