Alternative mass reference standards for direct analysis in real time mass spectrometry.
Rapid Commun Mass Spectrom
; 30(10): 1206-1212, 2016 05 30.
Article
em En
| MEDLINE
| ID: mdl-28328026
ABSTRACT
RATIONALE Mass spectra were acquired with the Direct Analysis in Real Time (DART®) ion source for an amine-terminated polyether used as positive-ion mass reference standards and for several fluorinated materials commonly used as negative-ion reference standards for mass spectrometry. METHODS:
A commercial time-of-flight mass spectrometer equipped with a DART ion source was used for all measurements. Mass reference standards deposited onto the sealed end of a glass melting point tube were suspended in the DART gas stream for analysis.RESULTS:
A polyetheramine (Jeffamine® M-600) produced intense peaks corresponding to protonated molecules. Perfluorotributylamine (PFTBA), and perfluorotripentylamine, gave useful reference spectra for different m/z ranges. DART mass spectra of Ultramark 1621® resembled those previously reported for Fast Atom Bombardment (FAB) and Electrospray Ionization (ESI). Fomblin®Y, a fluorinated ether, was the most useful negative-ion reference standard of the materials tested. The material is commercially available, inexpensive, and provides reference peaks covering the m/z range 85 to >3000.CONCLUSIONS:
Jeffamine-M600 was found to be a convenient alternative to polyethers such as polyethylene glycol (PEG) for DART positive-ion mass calibration. Fomblin Y was suitable for use as a negative-ion reference standard. Copyright © 2016 John Wiley & Sons, Ltd.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos