Poikiloderma with Neutropenia in Morocco: a Report of Four Cases.
J Clin Immunol
; 37(4): 357-362, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28353165
ABSTRACT
PURPOSE:
Poikiloderma with Neutropenia (PN) is inherited genodermatosis which results from a biallelic mutation in the USB1 gene (U Six Biogenesis 1). PN, first described in Navajo Native Americans, is characterized by early onset poikiloderma, pachyonychia, palmo-plantar hyperkeratosis, and permanent neutropenia. This condition results in frequent respiratory tract infections during infancy and childhood. From 2011 to 2013, four cases of PN were diagnosed in Morocco. In this paper, we report the first four cases of PN diagnosed in Morocco, out of three unrelated consanguinous families.METHODS:
We investigated the genetic, immunological, and clinical features of four Moroccan patients with PN from three unrelated consanguinous families.RESULTS:
Mean age at onset was 3 months and mean age at diagnosis was 7.5 years. The diagnosis of these PN patients was made based on clinical features and confirmed by molecular analysis for three cases. We identified two undescribed homozygous mutations in the USB1 gene c.609 + 1G>A in two siblings and c.518 T>G(p.(Leu173Arg)) in the other case.CONCLUSION:
This report confirms the clinical and genetic identity of Poikiloderma with Neutropenia syndrome.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Anormalidades da Pele
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Diester Fosfórico Hidrolases
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Infecções
/
Mutação
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Neutropenia
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Clin Immunol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Marrocos