Intraspecies comparative genomics of three strains of Orientia tsutsugamushi with different antibiotic sensitivity.
Genom Data
; 12: 84-88, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28393016
ABSTRACT
We recently reported the genome of Orientia tsutsugamushi (OT) strain Karp (GenBank Accession # NZ_LYMA00000000.2, https//www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2) with > 2 Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession # NZ_LYMT00000000.1, https//www.ncbi.nlm.nih.gov/nuccore/1035784408) and AFSC7 (GenBank Accession # NZ_LYMB00000000.1, https//www.ncbi.nlm.nih.gov/nuccore/1035854767) were more resistant to antibiotics than strain Karp, we conducted comparative analysis of the three draft genomes annotated by RAST server aimed to identify possible genetic bases of difference in microbial antibiotic sensitivity. Intraspecies comparative genomics analysis of the three OT strains revealed that two ORFs encoding hypothetical proteins in both strains AFSC4 and AFSC7 are absent in strain Karp.
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Bases de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Genom Data
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos