IL-21 is required for CD4 memory formation in response to viral infection.
JCI Insight
; 2(7): e90652, 2017 04 06.
Article
em En
| MEDLINE
| ID: mdl-28405614
ABSTRACT
IL-21 has been shown to play an important role in the CD8 T cell response during acute and chronic viral infections. However, the role of IL-21 signaling in the CD4 T cell response to viral infection remains incompletely defined. In a model of infection with vaccinia virus, we show that intrinsic IL-21 signaling on CD4 T cells was critical for the formation of memory CD4 T cells in vivo. We further reveal that IL-21 promoted CD4 T cell survival in a mechanism dependent on activation of the STAT1 and STAT3 signaling pathways. In addition, the activation of Akt is also required for IL-21-dependent survival of CD4 T cells in vivo. These results identify a critical role for intrinsic IL-21 signaling in CD4 T cell survival and memory formation in response to viral infection in vivo and may provide insights into the design of effective vaccine strategies.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vacínia
/
Linfócitos T CD4-Positivos
/
Transdução de Sinais
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Interleucinas
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Memória Imunológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
JCI Insight
Ano de publicação:
2017
Tipo de documento:
Article