Daphnetin reduces endotoxin lethality in mice and decreases LPS-induced inflammation in Raw264.7 cells via suppressing JAK/STATs activation and ROS production.

Shen, Lei; Zhou, Ting; Wang, Jing; Sang, Xiumei; Lan, Lei; Luo, Lan; Yin, Zhimin

Shen, Lei; Zhou, Ting; Wang, Jing; Sang, Xiumei; Lan, Lei; Luo, Lan; Yin, Zhimin.

Afiliação

Shen L; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China.
Zhou T; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China.
Wang J; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China.
Sang X; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China.
Lan L; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China. lanlei1978@gmail.com.
Luo L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China. lanluo@nju.edu.cn.
Yin Z; Jiangsu Province Key Laboratory for Molecular Biotechnology, College of Life Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210046, Jiangsu, People's Republic of China. yinzhimin@njnu.edu.cn.

Inflamm Res ; 66(7): 579-589, 2017 Jul.

Article em En | MEDLINE | ID: mdl-28409189

Assuntos

Lesão Pulmonar Aguda/tratamento farmacológico; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Endotoxemia/tratamento farmacológico; Umbeliferonas/farmacologia; Umbeliferonas/uso terapêutico; Lesão Pulmonar Aguda/metabolismo; Lesão Pulmonar Aguda/patologia; Animais; Ciclo-Oxigenase 2/metabolismo; Citocinas/metabolismo; Dinoprostona/metabolismo; Endotoxemia/metabolismo; Endotoxemia/patologia; Lipopolissacarídeos; Pulmão/efeitos dos fármacos; Pulmão/patologia; Masculino; Camundongos; Óxido Nítrico Sintase Tipo II/metabolismo; Proteínas Quinases/metabolismo; Células RAW 264.7; Espécies Reativas de Oxigênio/metabolismo; Fator de Transcrição STAT1/metabolismo; Fator de Transcrição STAT3/metabolismo

Palavras-chave

COX-2; Daphnetin; JAK/STATs; ROS; iNOS

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Umbeliferonas / Endotoxemia / Lesão Pulmonar Aguda / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article

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