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The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.
Schurich, Anna; Raine, Charles; Morris, Vanessa; Ciurtin, Coziana.
Afiliação
  • Schurich A; Division of Infection and Immunity, University College London, UK.
  • Raine C; Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.
  • Morris V; Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.
  • Ciurtin C; Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.
Rheumatology (Oxford) ; 57(2): 246-254, 2018 Feb 01.
Article em En | MEDLINE | ID: mdl-28541488
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Psoríase / Linfócitos T / Doenças Inflamatórias Intestinais / Interleucina-12 / Interleucina-23 Limite: Humans Idioma: En Revista: Rheumatology (Oxford) Assunto da revista: REUMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Psoríase / Linfócitos T / Doenças Inflamatórias Intestinais / Interleucina-12 / Interleucina-23 Limite: Humans Idioma: En Revista: Rheumatology (Oxford) Assunto da revista: REUMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article