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Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549).
Thakor, Parth; Subramanian, Ramalingam B; Thakkar, Sampark S; Ray, Arabinda; Thakkar, Vasudev R.
Afiliação
  • Thakor P; P. G. Department of Biosciences, Sardar Patel Maidan, Bakrol-Vadtal Road, Satellite Campus, Bakrol, Sardar Patel University, Vallabhvidyanagar, India. Electronic address: parth7218@gmail.com.
  • Subramanian RB; P. G. Department of Biosciences, Sardar Patel Maidan, Bakrol-Vadtal Road, Satellite Campus, Bakrol, Sardar Patel University, Vallabhvidyanagar, India.
  • Thakkar SS; Department of Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, India.
  • Ray A; Department of Organic Chemistry, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, India.
  • Thakkar VR; P. G. Department of Biosciences, Sardar Patel Maidan, Bakrol-Vadtal Road, Satellite Campus, Bakrol, Sardar Patel University, Vallabhvidyanagar, India. Electronic address: vasuthakkar@gmail.com.
Biomed Pharmacother ; 92: 491-500, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28575806
A number of drugs as well as lead molecules are isolated from natural sources. Phytol is one of such lead molecule belongs to terpenes group distributed widely in medicinal plants. In the present work, we investigated the cytotoxic behavior of phytol on human lung carcinoma cells (A549). Phytol was found to cause characteristic apoptotic morphological changes and generation of ROS in A549 cells. The mechanism of phytol involved the activation of TRAIL, FAS and TNF-α receptors along with caspase 9 and 3. In silico molecular docking studies revealed that phytol has a good binding affinity with glucose-6-phosphate dehydrogenase (G6PD), which is known to promote tumor proliferation. The ability of phytol to become potential drug candidate has been revealed from the pharmacokinetic study performed in the present study.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fitol / Espécies Reativas de Oxigênio / Caspase 3 / Caspase 9 / Glucosefosfato Desidrogenase / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fitol / Espécies Reativas de Oxigênio / Caspase 3 / Caspase 9 / Glucosefosfato Desidrogenase / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2017 Tipo de documento: Article