Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease.
Physiol Rev
; 97(3): 1211-1228, 2017 07 01.
Article
em En
| MEDLINE
| ID: mdl-28615463
ABSTRACT
The identification of the low-density lipoprotein receptor (LDLR) provided a foundation for subsequent studies in lipoprotein metabolism, receptor-mediated endocytosis, and many other fundamental biological functions. The importance of the LDLR led to numerous studies that identified homologous molecules and ultimately resulted in the description of the LDL-receptor superfamily, a group of proteins that contain domains also found in the LDLR. Subsequent studies have revealed that members of the LDLR-related protein family play roles in regulating many aspects of signal transduction. This review is focused on the roles of selected members of this protein family in skeletal development and disease. We present background on the identification of this subgroup of receptors, discuss the phenotypes associated with alterations in their function in human patients and mouse models, and describe the current efforts to therapeutically target these proteins to treat human skeletal disease.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Osteogênese
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Osso e Ossos
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Doenças Ósseas
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Regeneração Óssea
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Transdução de Sinais
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Proteínas Relacionadas a Receptor de LDL
Limite:
Animals
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Humans
Idioma:
En
Revista:
Physiol Rev
Ano de publicação:
2017
Tipo de documento:
Article