A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.

Lepeta, Katarzyna; Purzycka, Katarzyna J; Pachulska-Wieczorek, Katarzyna; Mitjans, Marina; Begemann, Martin; Vafadari, Behnam; Bijata, Krystian; Adamiak, Ryszard W; Ehrenreich, Hannelore; Dziembowska, Magdalena; Kaczmarek, Leszek

Lepeta, Katarzyna; Purzycka, Katarzyna J; Pachulska-Wieczorek, Katarzyna; Mitjans, Marina; Begemann, Martin; Vafadari, Behnam; Bijata, Krystian; Adamiak, Ryszard W; Ehrenreich, Hannelore; Dziembowska, Magdalena; Kaczmarek, Leszek.

Afiliação

Lepeta K; Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Purzycka KJ; Department of RNA Structure and Function, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Pachulska-Wieczorek K; Department of RNA Structure and Function, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Mitjans M; Clinical Neuroscience, Max Planck Institute of Experimental Medicine, DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.
Begemann M; Clinical Neuroscience, Max Planck Institute of Experimental Medicine, DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.
Vafadari B; Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Bijata K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of RNA Biology and Functional Genomics, Warsaw, Poland.
Adamiak RW; Department of RNA Structure and Function, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Ehrenreich H; Clinical Neuroscience, Max Planck Institute of Experimental Medicine, DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany ehrenreich@em.mpg.de m.dziembowska@cent.uw.edu.pl l.kaczmarek@nencki.gov.pl.
Dziembowska M; Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland ehrenreich@em.mpg.de m.dziembowska@cent.uw.edu.pl l.kaczmarek@nencki.gov.pl.
Kaczmarek L; Laboratory of Molecular Basis of Synaptic Plasticity, Centre of New Technologies, University of Warsaw, Warsaw, Poland.

EMBO Mol Med ; 9(8): 1100-1116, 2017 08.

Article em En | MEDLINE | ID: mdl-28623238

Assuntos

Metaloproteinase 9 da Matriz/análise; Metaloproteinase 9 da Matriz/genética; Polimorfismo de Nucleotídeo Único; Esquizofrenia Paranoide/patologia; Sinapses/enzimologia; Regiões 3' não Traduzidas; Adolescente; Adulto; Idoso; Animais; Células Cultivadas; Doença Crônica; Modelos Animais de Doenças; Feminino; Proteína do X Frágil da Deficiência Intelectual/metabolismo; Estudos de Associação Genética; Humanos; Masculino; Camundongos; Pessoa de Meia-Idade; Neurônios/citologia; Conformação de Ácido Nucleico; Ligação Proteica; RNA Mensageiro/química; RNA Mensageiro/metabolismo; Adulto Jovem

Palavras-chave

Fragile X mental retardation protein; dendritic spine morphology; matrix metalloproteinase 9; phenotypebased genetic association study; singlenucleotide polymorphism

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Esquizofrenia Paranoide / Sinapses / Metaloproteinase 9 da Matriz / Polimorfismo de Nucleotídeo Único Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: EMBO Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Polônia

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