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Mesothelioma continues to increase even 40 years after exposure - Evidence from long-term epidemiological observation.
Swiatkowska, B; Szeszenia-Dabrowska, N.
Afiliação
  • Swiatkowska B; Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, The Reference Center for Asbestos Exposure & Health Risk Assessment, Poland. Electronic address: Beata.Swiatkowska@imp.lodz.pl.
  • Szeszenia-Dabrowska N; Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, The Reference Center for Asbestos Exposure & Health Risk Assessment, Poland.
Lung Cancer ; 108: 121-125, 2017 06.
Article em En | MEDLINE | ID: mdl-28625623
BACKGROUND: Because asbestos dust is considered one of the most dangerous types of dust for people's health, issues related to the effects of asbestos exposure still remain questions about the role of cessation of exposure. OBJECTIVES: The aim of the present study was to determine the importance of temporal patterns, especially the time since the end of exposure in the risk of pleural mesothelioma. METHODS: A total of 131 patients with pleural mesothelioma and 655 frequency matched by gender and year of birth controls enrolled in the health surveillance programme for asbestos-related diseases over the years 2000-2014, were included in the analysis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: The results show that the risk of pleural mesothelioma continued to increase even after 40 years since the last exposure. The estimated odds ratio for the subjects who had their last exposure 40 years ago, compared with the odds ratio of those who had their last exposure 5 years ago, was 2.68 (95%CI: 1.16-.621). We also observed that crocidolite exposure was associated with a very high significant mesothelioma risk, 5-fold higher for those working with mixed exposure compared to the subjects who worked only with chrysotile. CONCLUSIONS: Dose-response relationships in populations occupationally exposed are critical to the study related to environment asbestos contamination. Our findings confirm the strong evidence that mesothelioma risk increases along with the increasing time since exposure termination.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Amianto / Exposição Ocupacional / Mesotelioma Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Amianto / Exposição Ocupacional / Mesotelioma Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article