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Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial.
Gram, Anne Sofie; Bladbjerg, Else-Marie; Quist, Jonas Salling; Petersen, Martin Bæk; Rosenkilde, Mads; Stallknecht, Bente.
Afiliação
  • Gram AS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: asg@medicinraadet.dk.
  • Bladbjerg EM; Unit for Thrombosis Research, Department of Public Health, University of Southern Denmark and Department of Clinical Biochemistry, Hospital of South West Jutland, Denmark.
  • Quist JS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Petersen MB; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Rosenkilde M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Stallknecht B; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Atherosclerosis ; 265: 318-324, 2017 10.
Article em En | MEDLINE | ID: mdl-28679486
BACKGROUND AND AIMS: Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men. METHODS: We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m2) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VO2peak, n = 39) or vigorous intensity (VIG, ∼70% VO2peak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis. RESULTS: We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups. CONCLUSIONS: Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Meios de Transporte / Exercício Físico / Sobrepeso / Inflamação / Atividades de Lazer Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Meios de Transporte / Exercício Físico / Sobrepeso / Inflamação / Atividades de Lazer Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Ano de publicação: 2017 Tipo de documento: Article