Atrophic degeneration of cerebellum impairs both the reactive and the proactive control of movement in the stop signal paradigm.
Exp Brain Res
; 235(10): 2971-2981, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28717819
ABSTRACT
The cognitive control of movement suppression, including performance monitoring, is one of the core properties of the executive system. A complex cortical and subcortical network involving cerebral cortex, thalamus, subthalamus, and basal ganglia has been regarded as the neural substrate of inhibition of programmed movements. Using the countermanding task, a suitable tool to explore behavioral components of movement suppression, the contribution of the cerebellum in the proactive control and monitoring of voluntary action has been recently described in patients affected by focal lesions involving in particular the cerebellar dentate nucleus. Here, we evaluated the performance on the countermanding task in a group of patients with cerebellar degeneration, in which the cerebellar cortex was diffusely affected, and showed that they display additionally a longer latency in countermanding engaged movements. Overall, the present data confirm the role of the cerebellum in executive control of action inhibition by extending the contribution to reactive motor suppression.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
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Ataxia de Friedreich
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Ataxias Espinocerebelares
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Função Executiva
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Inibição Psicológica
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Atividade Motora
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Brain Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália