Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(&#945;-aminoalkyl)phosphinic acid derivatives against human breast cancer.

Dastan, Taner; Kocyigit, Umit M; Durna Dastan, Sevgi; Canturk Kilickaya, Pakize; Taslimi, Parham; Cevik, Ozge; Koparir, Metin; Orek, Cahit; Gulçin, Ilhami; Cetin, Ahmet

Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(α-aminoalkyl)phosphinic acid derivatives against human breast cancer.

Dastan, Taner; Kocyigit, Umit M; Durna Dastan, Sevgi; Canturk Kilickaya, Pakize; Taslimi, Parham; Cevik, Ozge; Koparir, Metin; Orek, Cahit; Gulçin, Ilhami; Cetin, Ahmet.

Afiliação

Dastan T; Department of Chemistry, Division of Organic Chemistry, Faculty of Arts and Sciences, Bingol University, Bingol, 12000, Turkey.
Kocyigit UM; Vocational School of Health Services, Cumhuriyet University, Sivas, 58140, Turkey.
Durna Dastan S; Department of Animal Nutrition and Zootechnics, Division of Biometry and Genetics, Faculty of Veterinary Medicine, Cumhuriyet University, Sivas, 58140, Turkey.
Canturk Kilickaya P; Department of Pharmaceutical Biotechnology, School of Pharmacy, Cumhuriyet University, Sivas, 58140, Turkey.
Taslimi P; Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, 25240, Turkey.
Cevik O; Department of Biochemistry, School of Pharmacy, Cumhuriyet University, Sivas, 58140, Turkey.
Koparir M; Department of Chemistry, Division of Organic Chemistry, Faculty of Arts and Sciences, Firat University, Elazig, 23169, Turkey.
Orek C; Department of Chemistry, Division of Organic Chemistry, Faculty of Arts and Sciences, Firat University, Elazig, 23169, Turkey.
Gulçin I; Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, 25240, Turkey.
Cetin A; Department of Chemistry, Division of Organic Chemistry, Faculty of Arts and Sciences, Bingol University, Bingol, 12000, Turkey.

J Biochem Mol Toxicol ; 31(11)2017 Nov.

Article em En | MEDLINE | ID: mdl-28833991

Assuntos

Antineoplásicos/farmacologia; Inibidores da Anidrase Carbônica/farmacologia; Inibidores da Colinesterase/farmacologia; Inibidores da Topoisomerase I/farmacologia; Inibidores da Topoisomerase II/farmacologia; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Neoplasias da Mama/tratamento farmacológico; Inibidores da Colinesterase/química; DNA Topoisomerases Tipo I/metabolismo; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Células Endoteliais da Veia Umbilical Humana; Humanos; Células MCF-7; Ácidos Fosfínicos/química; Inibidores da Topoisomerase I/química; Inibidores da Topoisomerase II/química

Palavras-chave

acetylcholinesterase; carbonic anhydrase; cytotoxicity; phosphinic acid; topoisomerase

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Inibidores da Anidrase Carbônica / Inibidores da Colinesterase / Inibidores da Topoisomerase I / Inibidores da Topoisomerase II / Antineoplásicos Limite: Female / Humans Idioma: En Revista: J Biochem Mol Toxicol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia

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