The effects of UDP-sugars, UDP and Mg<sup>2+</sup>on uridine diphosphate glucuronosyltransferase activity in human liver microsomes.

Walia, Gurinder; Smith, Alexander D; Riches, Zoe; Collier, Abby C; Coughtrie, Michael W H

The effects of UDP-sugars, UDP and Mg²⁺on uridine diphosphate glucuronosyltransferase activity in human liver microsomes.

Walia, Gurinder; Smith, Alexander D; Riches, Zoe; Collier, Abby C; Coughtrie, Michael W H.

Afiliação

Walia G; a Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver , Canada.
Smith AD; a Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver , Canada.
Riches Z; a Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver , Canada.
Collier AC; a Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver , Canada.
Coughtrie MWH; a Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver , Canada.

Xenobiotica ; 48(9): 882-890, 2018 Sep.

Article em En | MEDLINE | ID: mdl-28868965

Assuntos

Glucuronosiltransferase/metabolismo; Magnésio/farmacologia; Microssomos Hepáticos/efeitos dos fármacos; Açúcares de Uridina Difosfato/farmacologia; Difosfato de Uridina/farmacologia; Alameticina/farmacologia; Humanos; Microssomos Hepáticos/metabolismo

Palavras-chave

Drug metabolism; glucuronidation; glycosylation; in vitroin vivo extrapolation; kinetics; substrate inhibition

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Difosfato de Uridina / Açúcares de Uridina Difosfato / Microssomos Hepáticos / Glucuronosiltransferase / Magnésio Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá

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