A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri.
BMC Genomics
; 18(1): 693, 2017 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-28874118
ABSTRACT
BACKGROUND:
The short-lived fish Nothobranchius furzeri is the shortest-lived vertebrate that can be cultured in captivity and was recently established as a model organism for aging research. Small non-coding RNAs, especially miRNAs, are implicated in age dependent control of gene expression.RESULTS:
Here, we present a comprehensive catalogue of miRNAs and several other non-coding RNA classes (ncRNAs) for Nothobranchius furzeri. Analyzing multiple small RNA-Seq libraries, we show most of these identified miRNAs are expressed in at least one of seven Nothobranchius species. Additionally, duplication and clustering of N. furzeri miRNAs was analyzed and compared to the four fish species Danio rerio, Oryzias latipes, Gasterosteus aculeatus and Takifugu rubripes. A peculiar characteristic of N. furzeri, as compared to other teleosts, was a duplication of the miR-29 cluster.CONCLUSION:
The completeness of the catalogue we provide is comparable to that of the zebrafish. This catalogue represents a basis to investigate the role of miRNAs in aging and development in this species.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ciprinodontiformes
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Biblioteca Gênica
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RNA não Traduzido
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MicroRNAs
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Longevidade
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
BMC Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha