Hypervalent aryliodine compounds as precursors for radiofluorination.
J Labelled Comp Radiopharm
; 61(3): 196-227, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28981159
ABSTRACT
Over the last 2 decades or so, hypervalent iodine compounds, such as diaryliodonium salts and aryliodonium ylides, have emerged as useful precursors for labeling homoarenes and heteroarenes with no-carrier-added cyclotron-produced [18 F]fluoride ion (t1/2 = 109.8 min). They permit rapid and effective radiofluorination at electron-rich as well as electron-deficient aryl rings, and often with unrestricted choice of ring position. Consequently, hypervalent aryliodine compounds have found special utility as precursors to various small-molecule 18 F-labeling synthons and to many radiotracers for biomedical imaging with positron emission tomography. This review summarizes this advance in radiofluorination chemistry, with emphasis on precursor synthesis, radiofluorination mechanism, method scope, and method application.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Radioisótopos de Flúor
/
Compostos Radiofarmacêuticos
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos