Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition.

Suzuki, Toshio; Tada, Yuji; Gladson, Santhi; Nishimura, Rintaro; Shimomura, Iwao; Karasawa, Satoshi; Tatsumi, Koichiro; West, James

Suzuki, Toshio; Tada, Yuji; Gladson, Santhi; Nishimura, Rintaro; Shimomura, Iwao; Karasawa, Satoshi; Tatsumi, Koichiro; West, James.

Afiliação

Suzuki T; Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. toshio.suzuki@vanderbilt.edu.
Tada Y; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan. toshio.suzuki@vanderbilt.edu.
Gladson S; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Nishimura R; Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Shimomura I; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Karasawa S; Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tatsumi K; Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
West J; Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Respir Res ; 18(1): 177, 2017 10 16.

Article em En | MEDLINE | ID: mdl-29037205

Assuntos

Adamantano/análogos & derivados; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Lipopolissacarídeos/toxicidade; Lesão Pulmonar/tratamento farmacológico; Nitrilas/uso terapêutico; Fibrose Pulmonar/tratamento farmacológico; Pirrolidinas/uso terapêutico; Adamantano/farmacologia; Adamantano/uso terapêutico; Animais; Inibidores da Dipeptidil Peptidase IV/farmacologia; Inibidores da Dipeptidil Peptidase IV/uso terapêutico; Transição Epitelial-Mesenquimal/fisiologia; Lesão Pulmonar/induzido quimicamente; Lesão Pulmonar/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Nitrilas/farmacologia; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/metabolismo; Pirrolidinas/farmacologia; Vildagliptina

Palavras-chave

Dipeptidyl peptidase 4; Endothelial-to-mesenchymal transition; Post ARDS pulmonary fibrosis; Pulmonary fibrosis

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Pirrolidinas / Adamantano / Lipopolissacarídeos / Lesão Pulmonar / Transição Epitelial-Mesenquimal / Nitrilas Limite: Animals Idioma: En Revista: Respir Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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