Increase in circulating holotranscobalamin after oral administration of cyanocobalamin or hydroxocobalamin in healthy adults with low and normal cobalamin status.
Eur J Nutr
; 57(8): 2847-2855, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-29038891
ABSTRACT
PURPOSE:
To investigate the absorption of synthetic cyanocobalamin and natural occurring hydroxocobalamin in populations with low and normal cobalamin (vitamin B12) status.METHODS:
We included adults with low (n = 59) and normal (n = 42) cobalamin status and measured the change in serum holotranscobalamin (ΔholoTC) before and after 2 day administration of different doses of cyanocobalamin and hydroxocobalamin (CobaSorb test). In the low status group, the test was performed using a cross-over design with identical doses of both cobalamin forms (1.5, 3, and 6 µg, respectively). In the normal status group, the test was performed with either 3, 6, and 9 µg cyanocobalamin (n = 28), or with 9 µg cyanocobalamin and 9 µg hydroxocobalamin (n = 14).RESULTS:
In both groups, median ΔholoTC (pmol/L) was higher after intake of cyanocobalamin compared to (hydroxocobalamin) [low status 1.5 µg 19 (6); 3 µg 23 (7); 6 µg 30 (14); normal status 9 µg 30 (13) pmol/L]. Independent of B12 form, no difference was observed in ΔholoTC between those receiving 1.5 and 3 µg in the low status group or 6 and 9 µg cyanocobalamin in the normal status group. However, in both groups, administration of 6 µg cobalamin resulted in a significant higher ΔholoTC than did 3 µg [low status p = 0.02 (0.009) for cyanocobalamin (hydroxocobalamin); normal status p = 0.03 for cyanocobalamin].CONCLUSIONS:
Administration of cyanocobalamin resulted in a more than twofold increase in holoTC in comparison with hydroxocobalamin. The absorptive capacity was reached only by doses above 3 µg cobalamin. Our results underscore the importance of using the same form of cobalamin when comparing uptake under different conditions. CLINICAL TRIAL REGISTRY NUMBER NCT02832726 at https//clinicaltrials.gov and 2016/09/012147 at Clinical Trials Registry India.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vitamina B 12
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Transcobalaminas
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Hidroxocobalamina
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Dinamarca